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Phytocannabinoids as anti-inflammatory agents: Synergistic effects when combined with Cannabis sativa L. matrices Source / Quelle: https://www.sciencedirect.com/science/article/pii/S0378874125018276?via%3Dihub Abstract Ethnopharmacological relevance Cannabis sativa L. has a long history of traditional use for the treatment of pain and inflammatory disorders in both Asian and European medical systems, which supports its investigation as a source of bioactive compounds with potential relevance for chronic immune-mediated diseases. Aim of the study This study evaluated the ten major non-psychotropic phytocannabinoids for their anti-inflammatory and antioxidant activities, and for synergistic interactions with non-cannabinoid matrices derived from the same plant (polar, non-polar and terpenoid). Material and methods Anti-inflammatory effects were assessed in macrophage-differentiated THP-1 cells by measuring pro-inflammatory cytokine production (ELISA) and nuclear factor kappa B (NF-κB) pa

The role of cannabidiol treatment in reducing HER2 expression and inducing ER stress-mediated apoptosis in HER2-positive breast cancer Source / Quelle: https://link.springer.com/article/10.1186/s12906-026-05523-y Abstract Background Cannabidiol (CBD) has attracted attention as a potential anticancer agent due to its observed efficacy, particularly in breast cancer. However, the exact molecular pathway through which it exerts its anticancer effects remains unknown. The present study aimed to investigate the effects of CBD on the HER2 receptor, endoplasmic reticulum (ER) stress signaling pathway, and apoptosis in HER2-positive breast cancer cells, as well as to examine the effect of trastuzumab (TZB), used in treatment, on the ER stress signaling pathway. Methods For this purpose, SKBR3 cells were treated with CBD at three different concentrations (9.38, 18.75, and 37.5 µM), TZB at 62.5 µg/mL, and two combinations of TZB and CBD (18.75 µM CBD + 62.5 µg/mL TZB and 37.5 µM CBD + 62.5 µg/mL

In vitro antimicrobial activity of Cannabis sativa extracts against Methicillin-resistant Staphylococcus aureus (MRSA) Source / Quelle: https://www.sciencedirect.com/science/article/pii/S0254629926004242 Abstract Cannabis sativa is a medicinal plant with promising antimicrobial properties, and humans have been utilising it for thousands of years as a source of food (seeds) and medicine. Antimicrobial resistance remains a significant challenge worldwide, making it difficult to manage microbial infections caused by multidrug-resistant strains. This study assessed the antimicrobial activity of two Cannabis sativa strains from Limpopo Province, South Africa, against multidrug-resistant microorganisms. Methanol and distilled water extracts of the two Cannabis sativa strains were prepared using maceration extraction, and the antimicrobial activity was assessed using standardised assays. Phytochemical constituents of the extracts were analysed using standard qualitative screening methods. Met

Efficacy of cannabinoids for insomnia and sleep disturbance: A systematic review and meta-analysis of randomized controlled trials Source / Quelle: https://www.sciencedirect.com/science/article/abs/pii/S1389945726004326 Abstract Background Insomnia is a common sleep disorder that presents with difficulty falling asleep or staying asleep. Standard hypnotics often lead to tolerance and dependency, prompting interest in cannabinoids as alternative sleep aids. This study evaluated the efficacy and safety of cannabinoids in improving sleep among adults with insomnia or poor sleep quality. Methods PubMed, EMBASE, Cochrane Library, Scopus, and Web of Science were searched from inception to January 2025 for randomized controlled trials (RCTs) comparing cannabinoids with placebo or melatonin. Primary outcomes were changes in Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI). Pooled mean differences (MD) or risk ratios (RR) with 95% confidence intervals (CI) were calculated

Cannabinoids and skin cancer: Mechanistic insights, therapeutic potential, and translational perspectives Source / Quelle: https://www.sciencedirect.com/science/article/pii/S0014480026000067 Abstract Skin cancer represents a significant global healthcare challenge, with rising incidence and persistent gaps in effective long-term management. Recent evidence has identified the endocannabinoid system as an emerging therapeutic target offering novel pharmacological approaches for the prevention and treatment of various skin cancers. Cannabinoids, through modulation of the endocannabinoid system, have demonstrated antitumor activity by inhibiting tumor proliferation, angiogenesis, invasion, and metastasis and by inducing apoptosis and autophagy in malignant cells. This review synthesizes the most recent preclinical evidence on phytocannabinoids, endocannabinoids, and synthetic cannabinoids in melanoma and non-melanoma skin cancers, delineating receptor-dependent and receptor-independent mec

Source / Quelle: https://www.ncbi.nlm.nih.gov/books/NBK501587/ Summary of Use during Lactation The main psychoactive component of cannabis, tetrahydrocannabinol (THC), is excreted into breastmilk in small quantities. The duration of detection of THC in milk has ranged from 6 days to greater than 6 weeks in various studies. Computer modeling studies predicted a half-life in milk of 12 to 39 hours, which is consistent with a THC clearance from milk in 2.5 to 8 days. Concern has been expressed regarding the possible effects of cannabis on neurotransmitters, nervous system development and endocannabinoid-related functions.[1,2] A 1-year study found that daily or near daily use might retard the breastfed infant’s motor development, but not growth or intellectual development.[3] This and other studies[4,5] found that occasional maternal cannabis use during breastfeeding did not have any discernable effects on breastfed infants, but the studies were inadequate to rule out all long-term harm a