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The use of THC cutoff levels in blood and oral fluid for detecting impairment in frequent cannabis users who smoked cannabis the “evening before” Source / Quelle: https://link.springer.com/article/10.1007/s00213-026-07129-1 Abstract Rationale Some jurisdictions use blood delta-9-tetrahydrocannabinol (THC) thresholds of 2ng/mL and oral fluid THC thresholds of 25ng/mL for detection of impaired driving. Objectives This study assesses morning-after driving and cognitive performance following evening cannabis use in participants above or below the 2ng/mL blood and 25ng/mL oral-fluid THC thresholds. Methods This observational study included frequent cannabis users (≥ 4 times/week) who smoked their preferred cannabis at home the evening before laboratory testing. At the visit (12–15 h post-use), participants completed driving simulation trials and underwent cognitive testing (verbal free recall and trail making test). Blood and oral fluid samples were collected at the time of testing for cann

The association between prenatal exposure to cannabis with and without tobacco and early cognitive and language development in a sample of polysubstance-exposed children Source / Quelle: https://www.sciencedirect.com/science/article/pii/S0378378226000745?via%3Dihub Highlights • We tested whether children with prenatal cannabis and/or tobacco exposure had worse development. • Cannabis exposure was not associated with impaired cognitive or language development. • Co-exposure to tobacco was not associated with worse outcomes than cannabis alone. • Results may help reduce stigma among women who have used cannabis during pregnancy. Abstract Background Prenatal cannabis exposure may have adverse effects on development which could be amplified by co-exposure with tobacco. Objective This study examined whether prenatal cannabis exposure was associated with disrupted language or cognitive development, and whether co-exposure to tobacco was associated with worse outcomes than to cannabis alone.

Source / Quelle: https://www.ajpmonline.org/article/S0749-3797(26)00164-9/abstract Abstract Introduction Many young adults vape and smoke cannabis, but it remains unclear whether dual use increases the risk of respiratory problems. Methods This study analyzed the national longitudinal Population Assessment of Tobacco and Health Study. The sample included 5,211 young adults (aged 18–24 years) without prior respiratory or pulmonary conditions at Wave 6 who completed Wave 7. Multivariable logistic regressions examined longitudinal associations between baseline cannabis vaping and smoking and functionally important respiratory symptoms at follow-up, controlling for sociodemographics, other substance use, health conditions, obesity, and cannabis use frequency. Data were collected between 2021 and 2023 and analyzed in 2025. Results At baseline, 18.8% of young adults reported past 30-day cannabis vaping or smoking: 2.1% vaped only, 11.3% smoked only, and 5.3% both vaped and smoked. Overall, 2

Source / Quelle: https://www.sciencedirect.com/science/article/abs/pii/S0306460326001504?via%3Dihub Abstract Background Rapid cannabis legalization in the United States has heightened concern about prenatal exposure as social acceptance increases. While tobacco use during pregnancy has steadily declined, emerging evidence suggests cannabis use may be rising. We examined national trends in tobacco-only use, cannabis-only use, and co-use among pregnant individuals from 2015 to 2023 and identified associated sociodemographic factors. Methods We analyzed nationally representative 2015–2023 National Survey on Drug Use and Health data restricted to pregnant women ages 15–44 (N = 6,099). Outcomes were self-reported past-30-day tobacco-only use, cannabis-only use, and co-use. Weighted prevalence was estimated for 2015–2019, 2020, and 2021–2023. Multivariable logistic regressions for 2015–2019 and 2021–2023 assessed predictors relative to non-use, reporting adjusted odds ratios and average marg