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A Comparative Analysis of the Action Mechanisms of Cannabidiol, Cannabigerol, and Cannabinol in Human Cholangiocarcinoma Cell Lines Source / Quelle: https://www.mdpi.com/1420-3049/31/14/2446 Abstract Background: Chemoresistance remains a major obstacle in managing cholangiocarcinoma (CCA). The cannabis plant contains several phytocannabinoids, including cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN), which exhibit anticancer properties. However, to the best of our knowledge, their effects on CCA have not been previously investigated. This study aimed to explore the molecular mechanisms underlying the anticancer effects of CBD, CBG, and CBN in CCA cells. Methods: KKU-100 and KKU-452 cells were treated with varying concentrations of CBD, CBG, and CBN for 24 and 48 h. Cytotoxicity was assessed using the MTT assay, and half maximal inhibitory concentration (IC50) values were calculated. KKU 452 cells were further analyzed for apoptosis, mitochondrial membrane potential (MMP),

Cannabidiol Attenuates UVB-Induced Skin Inflammation via STAT3/c-Jun Suppression and Silicone Polymer—Based Topical Delivery Source / Quelle: https://academic.oup.com/jimmunol/article/215/Supplement_1/vkag141.1792/8744636 Abstract Introduction UVB radiation induces epidermal damage and inflammatory responses through immune-mediated pathways in the skin. Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has demonstrated anti-inflammatory effects in various disease models; however, its therapeutic application in UVB-induced skin inflammation remains limited by poor stability and low bioavailability, largely due to oxidative and photodegradative instability. Methods This study was designed with two objectives. First, we aimed to elucidate the intrinsic anti-inflammatory mechanism of CBD in UVB-induced keratinocyte inflammation, with a particular focus on STAT3/c-Jun signaling axis. Second, we sought to evaluate a silicone polymer—based delivery strategy

The use of THC cutoff levels in blood and oral fluid for detecting impairment in frequent cannabis users who smoked cannabis the “evening before” Source / Quelle: https://link.springer.com/article/10.1007/s00213-026-07129-1 Abstract Rationale Some jurisdictions use blood delta-9-tetrahydrocannabinol (THC) thresholds of 2ng/mL and oral fluid THC thresholds of 25ng/mL for detection of impaired driving. Objectives This study assesses morning-after driving and cognitive performance following evening cannabis use in participants above or below the 2ng/mL blood and 25ng/mL oral-fluid THC thresholds. Methods This observational study included frequent cannabis users (≥ 4 times/week) who smoked their preferred cannabis at home the evening before laboratory testing. At the visit (12–15 h post-use), participants completed driving simulation trials and underwent cognitive testing (verbal free recall and trail making test). Blood and oral fluid samples were collected at the time of testing for cann

Source / Quelle: https://www.cannabisbusinesstimes.com/top-stories/news/15831904/beyond-terpenes-the-emerging-science-of-cannabis-flavor?utm_source=&pu_ext_id=67070e12472a41ea097314e5 https://www.cannabisbusinesstimes.com/top-stories/news/15833368/the-flavor-labs-dont-measure-what-is-terpene-testing-missing Written by Craig Hartsough and published on Cannabis Business Times. Beyond Terpenes: The Emerging Science of Cannabis Flavor Terpenes are essential to cannabis aroma, but recent research shows flavor depends on far more than terpenes alone. Editor's note: This is Part I of a two-part series. You can read Part II, "The Flavor Labs Don’t Measure: What Is Terpene Testing Missing?" here. Terpenes are at the center of most conversations about cannabis flower tastes. The advent of terpene testing in cannabis was exciting and groundbreaking. Finally, we had a concrete way to describe why flower smells and tastes differently, and how those terpenes steer the “high.” Now that terpene testin

Cannabidiol-Dominant Cannabis sativa L. Inflorescence Extract Ameliorates Atopic Dermatitis by Modulating NLRP3 Inflammasome and JAK1/STAT6 Signaling in DNCB-Induced Mice Source / Quelle: https://www.mdpi.com/2072-6643/18/14/2382 Abstract Background/Objectives: Atopic dermatitis (AD) is a chronic inflammatory skin disorder requiring sustainable therapeutic alternatives. Cannabis sativa L. is a valuable industrial crop rich in bioactive secondary metabolites; its potential as a standardized functional ingredient for promoting skin health has not yet been fully investigated. This study aimed to evaluate the therapeutic effects of a chemically characterized C. sativa inflorescence ethanol extract (CSE) on AD. Methods: To evaluate the efficacy of CSE, phytochemical profiling was performed using UPLC, and its underlying molecular mechanisms were investigated in a DNCB-induced mouse model. Results: UPLC analysis was employed to establish the phytochemical profile, identifying 15 cannabinoids

Effects of cannabidiol in comparison to hormonal therapy on estrogen decline-induced memory impairments and endocannabinoid system in rats Source / Quelle: https://onlinelibrary.wiley.com/doi/10.1111/jne.70234 Abstract The aim of this study was to investigate the effects of cannabidiol (CBD) on memory deficits induced by ovariectomy and to directly compare its effects with those of hormone therapy, in order to better understand potential shared mechanisms related to menopause-associated cognitive decline, with a particular focus on the endocannabinoid system. Three-month-old female Wistar rats were randomly assigned to four experimental groups: SHAM-Veh (Vehicle), OVX-Veh, OVX-E2 (estradiol), and OVX-CBD. Animals underwent either bilateral ovariectomy or sham surgery. Following a three-week recovery period, rats received daily subcutaneous injections of CBD (10 mg/kg), estradiol (10 μg/kg), or vehicle for 21 consecutive days. Behavioral assessments included object recognition and fear-